diff --git a/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_gen.py b/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_gen.py
new file mode 100644
index 00000000..b81f5caa
--- /dev/null
+++ b/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_gen.py
@@ -0,0 +1,64 @@
+from opencompass.openicl.icl_prompt_template import PromptTemplate
+from opencompass.openicl.icl_retriever import ZeroRetriever
+from opencompass.openicl.icl_inferencer import GenInferencer
+from opencompass.openicl.icl_evaluator import AccEvaluator
+from opencompass.utils.text_postprocessors import first_capital_postprocess
+from opencompass.datasets import PromptCBLUEDataset
+
+# 1. 子数据集名称
+PromptCBLUE_lifescience_sets = [
+    'CHIP-CDN', 'CHIP-CTC', 'KUAKE-QIC', 'IMCS-V2-DAC',
+    'CHIP-STS', 'KUAKE-QQR', 'KUAKE-IR', 'KUAKE-QTR'
+]
+
+# 2. Reader 配置
+reader_cfg = dict(
+    input_columns=['input', 'answer_choices', 'options_str'],
+    output_column='target',
+    train_split='dev',
+)
+
+# 3. Prompt 模板：末行固定 ANSWER: $LETTER
+_HINT = 'Given the ICD-10 candidate terms below, choose the normalized term(s) matching the original diagnosis.'
+
+query_template = f"""{_HINT}
+
+Original diagnosis: {{input}}
+
+Options:
+{{options_str}}
+
+The last line of your response must be exactly:
+ANSWER: $LETTER
+""".strip()
+
+infer_cfg_common = dict(
+    prompt_template=dict(
+        type=PromptTemplate,
+        template=dict(round=[dict(role='HUMAN', prompt=query_template)]),
+    ),
+    retriever=dict(type=ZeroRetriever),
+    inferencer=dict(type=GenInferencer),
+)
+
+# 4. 评估配置：与 MMLU 同款
+eval_cfg_common = dict(
+    evaluator=dict(type=AccEvaluator),
+    pred_postprocessor=dict(type=first_capital_postprocess),
+)
+
+# 5. 组装数据集配置
+promptcblue_datasets = []
+for ds_name in PromptCBLUE_lifescience_sets:
+    promptcblue_datasets.append(dict(
+        abbr=f'promptcblue_{ds_name.lower().replace("-", "_")}_norm',
+        type=PromptCBLUEDataset,
+        path='/fs-computility/ai4sData/shared/lifescience/tangcheng/LifeScience/opencompass_val/datasets/PromptCBLUE',
+        name=ds_name,
+        reader_cfg=reader_cfg,
+        infer_cfg=infer_cfg_common,
+        eval_cfg=eval_cfg_common,
+    ))
+
+# ★ OpenCompass 识别的出口变量
+datasets = promptcblue_datasets
diff --git a/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_llm_judge_gen.py b/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_llm_judge_gen.py
new file mode 100644
index 00000000..22de56a4
--- /dev/null
+++ b/opencompass/configs/datasets/PromptCBLUE/PromptCBLUE_llm_judge_gen.py
@@ -0,0 +1,102 @@
+from opencompass.openicl.icl_prompt_template import PromptTemplate
+from opencompass.openicl.icl_retriever import ZeroRetriever
+from opencompass.openicl.icl_inferencer import GenInferencer
+from opencompass.openicl.icl_evaluator import AccEvaluator
+from opencompass.evaluator import GenericLLMEvaluator
+from opencompass.datasets import generic_llmjudge_postprocess
+from opencompass.datasets import PromptCBLUEDataset
+
+PromptCBLUE_lifescience_sets = [
+    'CHIP-CDN', 'CHIP-CTC', 'KUAKE-QIC', 'IMCS-V2-DAC',
+    'CHIP-STS', 'KUAKE-QQR', 'KUAKE-IR', 'KUAKE-QTR'
+]
+# Query template (keep original)
+QUERY_TEMPLATE = """
+Given a medical diagnosis description and labeled ICD-10 candidate terms below, select the matching normalized term(s).
+Original diagnosis: {input}
+
+Options:
+{options_str}
+
+The last line of your response must be exactly in the format:
+ANSWER: <LETTER(S)>
+""".strip()
+
+# Grader template (keep original)
+GRADER_TEMPLATE = """
+As an expert evaluator, judge whether the candidate's answer matches the gold standard below.
+Return 'A' for CORRECT or 'B' for INCORRECT, with no additional text.
+
+Original diagnosis: {input}
+
+Options:
+{options_str}
+
+Gold answer: {target}
+
+Candidate answer: {prediction}
+""".strip()
+
+# Common reader config
+reader_cfg = dict(
+    input_columns=['input', 'answer_choices', 'options_str'],
+    output_column='target',
+    train_split='dev'
+)
+
+# Assemble LLM evaluation datasets
+promptcblue_llm_datasets = []
+for name in PromptCBLUE_lifescience_sets:
+    infer_cfg = dict(
+        prompt_template=dict(
+            type=PromptTemplate,
+            template=dict(round=[
+                dict(role='HUMAN', prompt=QUERY_TEMPLATE),
+            ]),
+        ),
+        retriever=dict(type=ZeroRetriever),
+        inferencer=dict(type=GenInferencer),
+    )
+
+    eval_cfg = dict(
+        evaluator=dict(
+            type=GenericLLMEvaluator,
+            prompt_template=dict(
+                type=PromptTemplate,
+                template=dict(
+                    begin=[
+                        dict(
+                            role='SYSTEM',
+                            fallback_role='HUMAN',
+                            prompt='You are an expert judge for medical term normalization tasks.',
+                        )
+                    ],
+                    round=[
+                        dict(role='HUMAN', prompt=GRADER_TEMPLATE),
+                    ],
+                )
+            ),
+            dataset_cfg=dict(
+                type=PromptCBLUEDataset,
+                path='/fs-computility/ai4sData/shared/lifescience/tangcheng/LifeScience/opencompass_val/datasets/PromptCBLUE',
+                name=name,
+                reader_cfg=reader_cfg,
+            ),
+            judge_cfg=dict(),
+            dict_postprocessor=dict(type=generic_llmjudge_postprocess),
+        ),
+        pred_role='BOT',
+    )
+
+    promptcblue_llm_datasets.append(
+        dict(
+            abbr=f"promptcblue_{name.lower().replace('-', '_')}_norm_llm",
+            type=PromptCBLUEDataset,
+            path='/fs-computility/ai4sData/shared/lifescience/tangcheng/LifeScience/opencompass_val/datasets/PromptCBLUE',
+            name=name,
+            reader_cfg=reader_cfg,
+            infer_cfg=infer_cfg,
+            eval_cfg=eval_cfg,
+            mode='singlescore',
+        )
+    )
diff --git a/opencompass/configs/datasets/PromptCBLUE/README.md b/opencompass/configs/datasets/PromptCBLUE/README.md
new file mode 100644
index 00000000..e69de29b
diff --git a/opencompass/datasets/PromptCBLUE.py b/opencompass/datasets/PromptCBLUE.py
new file mode 100644
index 00000000..0d71916e
--- /dev/null
+++ b/opencompass/datasets/PromptCBLUE.py
@@ -0,0 +1,61 @@
+import json
+import os.path as osp
+
+from datasets import Dataset, DatasetDict
+
+from opencompass.registry import LOAD_DATASET
+from opencompass.utils import get_data_path
+
+from .base import BaseDataset  # 保持与 MMLUDataset 同级的导包风格
+
+
+@LOAD_DATASET.register_module()
+class PromptCBLUEDataset(BaseDataset):
+    """Loader for PromptCBLUE life-science tasks (CHIP-CDN, CHIP-CTC …).
+
+    - 只读 `dev.json`。
+    - 保留指定 `task_dataset` 的所有任务类型（包括 normalization、cls 等）。
+    - 若 `target` 不在 `answer_choices`，自动追加；并生成 `options_str`
+      （形如 “A. 选项1\\nB. 选项2 …”）。
+    - 返回 `DatasetDict`，将 dev 复制到 test 以满足评估流程。
+    """
+
+    @staticmethod
+    def load(path: str, name: str, **kwargs):
+        path = get_data_path(path)
+        file_path = osp.join(path, 'dev.json')
+        if not osp.exists(file_path):
+            raise FileNotFoundError(f'`dev.json` not found under {path}')
+
+        records = []
+        with open(file_path, 'r', encoding='utf-8') as f:
+            for line in f:
+                rec = json.loads(line)
+                if rec.get('task_dataset') != name:
+                    continue  # 过滤子数据集
+
+                choices = rec.get('answer_choices', []).copy()
+                target = rec.get('target')
+                if target not in choices:
+                    choices.append(target)
+
+                options_str = '\n'.join(f'{chr(65+i)}. {opt}'
+                                        for i, opt in enumerate(choices))
+
+                records.append({
+                    'input': rec['input'],
+                    'answer_choices': choices,
+                    'options_str': options_str,
+                    'target': target,
+                })
+
+        # 保证列完整，即使 records 为空
+        if records:
+            ds = Dataset.from_list(records)
+        else:
+            ds = Dataset.from_dict({
+                k: []
+                for k in ['input', 'answer_choices', 'options_str', 'target']
+            })
+        dataset = DatasetDict(dev=ds, test=ds)  # dev 与 test 指向同一份
+        return dataset
diff --git a/opencompass/datasets/__init__.py b/opencompass/datasets/__init__.py
index b00162d1..c034715a 100644
--- a/opencompass/datasets/__init__.py
+++ b/opencompass/datasets/__init__.py
@@ -115,6 +115,7 @@ from .OlympiadBench import *  # noqa: F401, F403
 from .OpenFinData import *  # noqa: F401, F403
 from .physics import *  # noqa: F401, F403
 from .piqa import *  # noqa: F401, F403
+from .PromptCBLUE import PromptCBLUEDataset  # noqa: F401, F403
 from .py150 import *  # noqa: F401, F403
 from .qasper import *  # noqa: F401, F403
 from .qaspercut import *  # noqa: F401, F403